Metaheuristic approaches in biopharmaceutical process development data analysis

Fluorescence-based tools to improve biopharmaceutical process development

Background Process optimization and control are essential to match biopharmaceutical market demands. Early-steps in the development of new processes require screening hundreds of transfected clones in order to select those with the best expression characteristics, and identifying optimal environmental conditions for these clones to grow and express the protein of interest. While some culture sy...

New Challenges for Biopharmaceutical Process Development.PDF

The U.S. Food and Drug Administration (FDA), through the Center for Biologics Evaluation and Research (CBER)/Center for Drug Evaluation and Research (CDER), has long identified that the development of biopharmaceutical products is becoming increasingly challenging, and is inefficient and costly. The agency has also commented that superior product-development sciences are needed to address the c...

Biopharmaceutical Process Evaluated for Viral Clearance

© 2009 Microbac Laboratories, Inc. Page 1 of 7 The purpose of Viral Clearance evaluation is to assess the capability of a manufacturing production process to inactivate and/or remove potential viral contaminants. Experience and knowledge in selecting the most relevant target viruses, appropriate purification steps, and viral clearing agents are critical in the design and implementation of a cos...

Metaheuristic Approaches for Vehicle Routing Problems

Routing of service vehicles are the heart of many service operations. Exclusively vehicle routing problem (VRP) plays a central role in the optimization of distribution networks. The routing of service vehicles has a major impact on the quality of the service provided. In distribution of goods and services, it is time and again required to determine a combination of least cost vehicle routes th...

Metaheuristic Approaches for QoS Multicast Routing Problems